Method of delivering a lipid-coated condensed-phase microparticle composition
US5820879A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 18, 1995 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | May 18, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/586
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of delivering a therapeutic compound to an in vivo target site having a selected pH, temperature, ligand concentration or binding-molecule characteristic. The method includes entrapping the therapeutic compound in an encapsulated microparticle composition that, when exposed to a selected target stimulus related to pH, temperature, radiation, or the presence of a selected ligand or ion-channel activator, decondenses to release compound into the target site. The encapsulated microparticle composition consists of a condensed-phase particle matrix containing the compound to be delivered in entrapped form, and a stimulus-responsive lipid bilayer membrane formed around the matrix. Localized perturbation of the lipid membrane, and influx of monovalent counterions into the polymer matrix, in response to the selected target stimulus, causes matrix swelling and compound release from the particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.