LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents
US5821053A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 10, 1995 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | Feb 10, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for finding an agent which inhibits interaction between LIL-Stat protein and a nucleic acid having a LIL-Stat binding sequence is described. The LIL-Stat protein is contacted with the nucleic acid in the presence of an agent which inhibits or does not inhibit the interaction between the LIL-Stat protein and the nucleic acid. It is determined whether or not the agent inhibits this interaction. Also described are a method for treating an inflammatory response in a mammal, a therapeutic inhibitory agent suitable for treating or preventing an inflammatory response in a mammal, and DNA molecules having a DNA sequence encoding a binding site for the LIL-Stat protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.