Peptide having inflammation affinity and radioactive diagnostic containing the same
US5821330A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1994 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | Oct 21, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A peptide having affinity with inflammation is disclosed, which contains at least one of the following amino acid sequences: PA1 LLGGPS (SEQ ID NO:1), PA1 LLGGPSV (SEQ ID NO:2), PA1 KEYKAKVSNKALPAPIEKTISK (SEQ ID NO:3), PA1 KEYKCKVSNKALPAPIEKTISK (SEQ ID NO:4), PA1 KTKPREQQYNSTYR (SEQ ID NO:5), and PA1 KTKPREQQYNSTYRVV (SEQ ID NO:6), wherein A, C, E, G, I, K, L, N, P, Q, R, S, T, V, and Y represent amino acid residues expressed by standard one-letter symbols. According to the present invention, a peptide and its chemically modified substances, radioactive metal labeled peptides derived therefrom, and radioactive diagnostics comprising such peptide are provided, which are useful for imaging inflammation region and easy in preparation handling, and accumulate at inflammation site immediately after administration while being excellent in clearance into urine. The imaging is possible in several ten minutes after administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.