Receptor on the surface of activated CD4.sup.+ T-cells: ACT-4
US5821332A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 3, 1993 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | Nov 3, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides purified ACT-4 receptor polypeptides, antibodies against these polypeptides and nucleic acids encoding ACT-4 receptor polypeptides. Also provided are methods of diagnosis and treatment using the same. ACT-4 receptors are preferentially expressed on the surface of activated CD4.sup.+ T-cells. ACT-4 receptors are usually expressed at low levels on the surface of activated CD8.sup.+ cells, and are usually substantially absent on resting T-cells, and on monocytes and B-cells (resting or activated). An exemplary ACT-4 receptor, termed ACT-4-h-1, has a signal sequence, an extracellular domain comprising three disulfide-bonded intrachain loops, a transmembrane domain, and an intracellular domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.