Regiospecific process for synthesis of acyclic nucleosides
US5821367A · kind A · utility
1Cited by
2References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 5, 1996 |
| Grant date | Oct 13, 1998 |
| Priority date | — |
| Expiry date | Apr 5, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to an improved regiospecific process for the synthesis of acyclic nucleosides such as, acyclovir and ganciclovir, anti-viral compounds especially effective against herpes virus, and intermediates thereof starting from dyacylguanine and an alkylating agent, selected from 2-oxa-1,4-butanediol diacetate (OBDDA), 1,4-diacetoxy-3-acetoxymethyl-2-oxa-butane, 1,4-dibenzyloxy-3-acetoxymethyl-2-oxabutane. The reaction is carried out in the absence of an acid catalyst and a solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.