Leader-proteinase deleted foot-and-mouth disease viruses and their use as vaccines
US5824316A · kind A · utility
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Key dates
| Filing date | May 24, 1996 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | May 24, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32123
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A foot-and-mouth disease virus has been genetically engineered by deleting the nucleic acid sequence encoding the leader (L) proteinase from an infectious cDNA copy of the viral genome and producing an L proteinase-deleted virus. The L proteinase-deleted viruses are able to assemble and grow in cells in culture, but, since they lack L proteinase, they are less toxic to infected cells within the animal, producing an attenuated infection. The recombinant virus can be formulated into an effective vaccine for the prevention of foot-and-mouth disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.