Conformationally-restricted combinatiorial library composition and method
US5824483A · kind A · utility
116Cited by
3References
13Claims
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Key dates
| Filing date | Jun 16, 1995 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Jun 16, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B60/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Combinatorial libraries of different-sequence peptide members is disclosed. The libraries are comprised of stabilized, alpha-helical polypeptides having a similar tertiary structure but different amino acid residues at specific, "variable" positions in the sequence. The polypeptides are stabilized through coiled-coil interactions with other .alpha.-helical polypeptides and/or via intrahelical lactam bridges. Also disclosed are methods for using such libraries to screen for selected macromolecular ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.