High efficiency translation of mRNA molecules
US5824497A · kind A · utility
74Cited by
7References
19Claims
0Family size
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Key dates
| Filing date | Feb 10, 1995 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Feb 10, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/67
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An increased level of translation of a selected mRNA molecule is effected by coupling specific nucleotide sequences at the 5'- and 3'-ends of a nucleic acid molecule transcribable to or which itself is the mRNA molecule. The nucleotide sequence at the 5'-end is effective to increase the rate of translation initiation of the mRNA molecule in a cell while the nucleotide sequence at the 3'-end is effective to increase the period of translation of the mRNA molecule in a cell.
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