Tissue-specific and target RNA-specific ribozymes
US5824519A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1995 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Nov 8, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/021
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides tissue-specific and target RNA-specific ribozymes. These ribozymes can be used to destroy target-specific neoplasms and to treat viral infections, among other uses. The ribozymes of the present invention comprise a 5' autocatalytically cleaving ribozyme sequence, a catalytic ribozyme comprising a target RNA-specific binding site and a 3' autocatalytically cleaving ribozyme. The invention also provides nucleic acids which encode the ribozymes of the invention. These nucleic acids can be used to express the ribozymes of the invention at the selected site. Methods of treating disease by administering the ribozymes are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.