Chemotactic wound healing peptides
US5824647A · kind A · utility
19Cited by
6References
7Claims
0Family size
Inventors
Key dates
| Filing date | Jun 1, 1995 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Jun 1, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides corresponding to amino acid sequences in the C-terminal region of TGF-.beta. are provided. The peptides all contain at least a seven amino acid sequence substantially corresponding to the amino acid sequence of TGF-.beta.1 amino acids 368-374: VYYVGRK, as well as homologs and analogs thereof. The peptides have chemotactic activity towards fibroblasts, monocytes and neutrophils and induce fibroblast proliferation and collagen synthesis. The peptides may be used in compositions and methods for promoting wound healing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.