Process for modification of implant surface with bioactive conjugates for improved integration
US5824651A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 1996 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Jun 28, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/606
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention relates to a process for the covalent coating of implants with a bioactive conjugate, which comprises the steps of: a) cleaning a metal implant surface from contaminants by deoxidation with potentiostatic electrochemical polishing in a solution selected from ethanol, perchloric acid-butanol-methanol solution, H.sub.2 O.sub.2 --NaCl--NaH.sub.2 PO.sub.4 or by chemical cleaning with a solution selected from the group consisting of HF/HNO.sub.3, H.sub.2 O.sub.2 /H.sub.2 SO.sub.4 and H.sub.2 O.sub.2 /KOH; b) coating the cleaned implant surface of step a) with a bioactive conjugate, wherein the conjugate has the following structural Formula I: EQU --R--X--P I wherein, R is O or S, adapted to be covalently attached to an implant surface; X is selected from a bond, linear or branched chains of 1 to 30 covalently attached atoms of at least C, N, O, Si or S, rings of 1 to 20 covalently attached atoms of at least C, N, O, Si or S, and a combination thereof; and P is a bioactive molecule moiety which promotes tissue growth, stabilization and integration, and wherein the moiety retains its biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.