Guanidine derivatives as inhibitors of Na.sup.+ /H.sup.+ exchange in cells
US5824691A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 9, 1995 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Nov 9, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Guanidine derivatives of the formula: ##STR1## wherein Y is C--R.sup.1 PA2 (in which R.sup.1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) PA1 R.sup.2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., PA1 R.sup.3 is hydrogen, lower alkoxy, hydroxy, protected hydroxy, etc., PA1 Z is C--R.sup.4 PA2 (in which R.sup.4 is hydrogen, carboxy, protected carboxy, nitro, halogen, hydroxy(lower)alkyl, etc.,), and PA1 W is R.sup.12 PA2 (in which R.sup.12 is hydrogen, lower alkoxy, nitro, hydroxy or protected hydroxy) and pharmaceutically acceptable salts thereof which are useful as a medicament which are useful in inhibiting Na.sup.+ /H.sup.+ exchange in cells and in the prevention of cardiovascular diseases, cerebrovascular diseases, renal diseases, arteriosclerosis and shock.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.