Process for the preparation of iodinated contrast agents and intermediates therefor
US5824821A · kind A · utility
1Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 7, 1997 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Feb 7, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C237/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides a process for the production of a 2,3-dihydroxypropylamino compound, said process comprising the reaction steps of: PA1 (i) obtaining an allylamino compound; PA1 (ii) epoxidizing said allylamino compound to yield an epoxypropylamino compound; and PA1 (iii) hydrolysing said epoxypropylamino compound to yield a 2,3-dihydroxypropylamino compound. This process may be used to produce simple 2,3-dihydroxypropylamino compounds such as APD or complex ones such as BAPD (an intermediate in the production of iohexol).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.