Commercial production of aprotinin in plants
US5824870A · kind A · utility
13Cited by
4References
13Claims
0Family size
Inventors
Key dates
| Filing date | Nov 6, 1995 |
| Grant date | Oct 20, 1998 |
| Priority date | — |
| Expiry date | Nov 6, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A40/146
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for commercial production of aprotinin entails heterologous expression of the protein in plants, preferably at a level such that aprotinin accounts for at least 0.1% of the total extracted protein. An aprotinin-expressing plant also has potential of increased insecticidal resistance by virtue of producing the protein. A genetic map of the integration locus allows identification of plants derived from the transgenic plant. This approach also reveals genetic loci on a plant chromosome that support high levels of gene expression and can be used as site of integration for expression of other genes of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.