Antifungal polypeptide and process for its production

US5824874A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Norbert Ulbrich · Potsdam, DE
• Rolf Hilgenfeld · Friedrichsdorf, DE
• Heinz Hanel · Oberursel, DE
• Burkhard Sachse · Kelkheim, DE
• Peter Braun · Nieder-Olm, DE
• Joachim Wink · Rödermark, DE
• Peter Eckes · Kelkheim, DE
• Jurgen Logemann · Leiden, NL
• Jozef Schell · Neunburg vorm Wald, DE

Key dates

• Filing date: Jul 29, 1996
• Grant date: Oct 20, 1998
• Expiry date: Jul 29, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/823
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The polypeptide with the sequence (SEQ ID NO:1) Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys-Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Al a-Lys-Cys-Glu-Phe-Asp-Ser-Tyr-Lys-Gly-Lys-Cys-Tyr-Cys can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent. Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.