Transistor-based apparatus and method for molecular detection and field enhancement
US5827482A · kind A · utility
52Cited by
6References
28Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 20, 1996 |
| Grant date | Oct 27, 1998 |
| Priority date | — |
| Expiry date | Aug 20, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54373
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Binding of a molecule to a molecular receptor is sensed using a transistor having a gate located at a binding site. The channel conductance of the transistor is modified by a charge associated with the molecule when the molecule binds with the molecular receptor. A modified electrical characteristic of the transistor which results is sensed to sense the binding event. Electric field enhancement is provided by applying a voltage to the gate. A second sensing transistor can be coupled to the sensing transistor to form a differential pair. The differential pair allows for enhancing and sensing of differential binding events.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.