Use of free radicals in ESR and ESREMR imaging

US5827501A · kind A · utility

Assignee

• NYCOMED IMAGING AS · NO

Inventors

• Mikkel J.o slashed.rgensen · Taastrup, DK
• Frode Rise · Vinstra, NO
• Sven Andersson · Malmö, SE
• Torsten Almen · Malmö, SE
• Arne Wang Aabye · Oslo, NO
• Lars-Goran Wistrand · Oslo, NO
• Hakan Wikstrom · Groningen, NL
• Klaes Golman · Hørsholm, DK
• Rolf Servin · Malmö, SE
• Peter Michelsen · Arlöv, SE

Key dates

• Filing date: Jun 7, 1995
• Grant date: Oct 27, 1998
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.