In vitro cornea equivalent model
US5827641A · kind A · utility
Inventors
Key dates
| Filing date | Nov 8, 1994 |
| Grant date | Oct 27, 1998 |
| Priority date | — |
| Expiry date | Nov 8, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro. This invention is also directed to the use of endothelial cells in other tissue and organ equivalents to promote basement membrane development. The cornea equivalent comprises an inner endothelial cell layer, a middle stromal cell and collagen mixture wherein the stromal cells are derived from fibroblast cells and an external epithelial cell layer, wherein the epithelial cells are derived from corneal epithelial cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.