Patent · US Expired

Method of increasing viability of stored erythrocytes by addition of lipoic, dihydrolipoic, 6,8-bisnortetralipoic, or tetranorlipoic acid

US5827643A · kind A · utility

9Cited by

1References

6Claims

0Family size

Assignee

Asta Medica Aktiengesellschaft · DE

Inventors

Frank Conrad
Hermann-August Henrich · Würzburg, DE
Wolfgang Geise · Dipbach, DE
Heinz Ulrich · Niedernberg, DE

Key dates

Filing date	Nov 8, 1995
Grant date	Oct 27, 1998
Priority date	—
Expiry date	Nov 8, 2015

Classification

Technology area (CPC A)Human Necessities
CPC primaryA01N1/126
WIPO fieldBasic materials chemistry
WIPO sectorChemistry

Abstract

A method of improving the properties of liquid stored or cryogenically stored erythrocytes using D,L-.alpha.-lipoic acid and/or enantiomers or derivatives thereof. Treatment with these substances results in improved oxygen release capacity (2,3-DPG), viscoelasticity and erythrocyte aggregability, and increased resistance to membrane peroxidation during storage and damage by the freeze/thaw process.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.