Adipogenic differentiation of human mesenchymal stem cells
US5827740A · kind A · utility
196Cited by
1References
14Claims
0Family size
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Key dates
| Filing date | Jul 30, 1996 |
| Grant date | Oct 27, 1998 |
| Priority date | — |
| Expiry date | Jul 30, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/39
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogenic lineage, and a process for inducing such differentiation. The composition for inducing such differentiation comprises a glucocorticoid and a compound which stimulates cAMP production or inhibits cAMP degradation (such as a phosphodiesterase inhibitor). The process can further include isolating the adipocytes from remaining hMSCs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.