Conformationally stabilized cell adhesion peptides
US5827821A · kind A · utility
16Cited by
20References
29Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 16, 1992 |
| Grant date | Oct 27, 1998 |
| Priority date | — |
| Expiry date | Jul 16, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occurring amino acid, or by other methods. In particular, there are provided cyclic peptides having increased affinity and selectivity for the certain receptors over that of linear, Arg-Gly-Asp-containing synthetic peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.