Carbazole derivatives as agents against multi-drug resistance
US5827846A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 27, 1996 |
| Grant date | Oct 27, 1998 |
| Priority date | — |
| Expiry date | Nov 27, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/044
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The utility of known and novel staurosporin derivatives of formula I ##STR1## wherein R.sub.1 is formyl, an aliphatic hydrocarbon radical having up to 29 carbon atoms that is unsubstituted or substituted by aryl, or is an aryl radical, PA1 R.sub.2 is hydrogen, C.sub.1 -C.sub.5 alkyl, benzoyl, lower alkanoyl or .alpha.-aminoacyl having a free or protected amino group, and PA1 R.sub.3 is hydrogen, hydroxy, lower alkoxy or oxo, or wherein PA1 R.sub.1 is methoxycarbonylmethyl, PA1 R.sub.2 is benzoyl, and PA1 R.sub.3 is hydrogen, for avoiding or removing multi-drug resistance to anti-tumour agents, such as vinblastine or adriamycin, is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.