Skin vibration method for topical targeted delivery of beneficial agents into hair follicles
US5830177A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1996 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Nov 22, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61H2205/021
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a methods and apparatuses for use in providing rapid, selective and effective targeted delivery of beneficial substances into hair follicles. The invention relies on the use of vibrational method of delivery of substances of different size from small molecules up to particles compatible with the diameter of hair strand into the hair bulb. The skin is subjected to the vibration of about 1 Hz to about 100 Hz frequency and 0.1 mm to about 10 mm amplitude, an amount which is sufficient to cause mechanical shifts in different directions of skin structure without damage. This results in follicle effective uptake of the tested substances such as carbon particles of different size as well as melanin. The methods and apparatuses of the present invention are particularly useful in conjunction with photosensitive agents and electromagnetic irradiation. Such a combination is used to target the delivery of the agent to within hair follicles and then subsequently activate the agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.