Radiolabeled growth hormone secretagogue

US5830433A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Dennis C. Dean · Chatham, US
• David G. Melillo · Scotch Plains, US
• Ravi Nargund · East Brunswick Township, US
• Leonardus H. T. Van Der Ploeg · Newton, US
• Sheng-Shung Pong · Edison, US
• James M. Schaeffer · Westfield, US
• Roy G. Smith · Houston, US

Key dates

• Filing date: Dec 17, 1996
• Grant date: Nov 3, 1998
• Expiry date: Dec 17, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to .sup.35 S!-N-1(R)-(1,2-dihydro-1-methanesulfonylspiro3H-indole-3,4'-piperidin!- 1'-yl)carbonyl!-2-(phenylmethyloxy)ethyl!-2-amino-2-methylpropanamide, and pharmaceutically acceptable salts thereof. This .sup.35 S! radioligand is useful in identifying and characterizing cellular receptors which play a role in the activity of growth hormone secretatogogues. In addition, this .sup.35 S! radioligand is useful in assays which test compounds for growth hormone secretagogue activity.