Neurokinin A antagonists

US5830863A · kind A · utility

Assignee

• Merrell Pharmaceuticals, Inc. · US

Inventors

• Stephen H. Buck · Cincinnati, US
• Scott L. Harbeson · Cambridge, US
• John L. Krstenansky · Palo Alto, US
• Chester F. Hassman, III · Durham, US
• James R. McCarthy · Dorpsstraat, US

Key dates

• Filing date: Dec 13, 1996
• Grant date: Nov 3, 1998
• Expiry date: Dec 13, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antagonists of neurokinin A which are derivatives of naturally occurring neurokinin A in which the amide bond connecting the two amino acids on the carboxy terminal end is modified are described. The antagonism is confirmed using conventional competitive binding and biochemical assays as well as conventional physiological tests and the use of these derivatives in a variety of conditions in which neurokinin A is implicated is also described.