Hemoregulatory peptides for stimulating the myelopoietic system

US5830867A · kind A · utility

Assignees

• SmithKline Beecham Limited · US
• NYCOMED PHARMA AS · NO

Inventors

• Pradip Kumar Bhatnagar · Exton, US
• Dirk Heerding · Malvern, US
• Peter Fischer · Oslo, NO

Key dates

• Filing date: Jan 30, 1996
• Grant date: Nov 3, 1998
• Expiry date: Jan 30, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of the general formula (I): EQU A.sup.1 --B.sup.1 --X.sup.1 --(CH.sub.2).sub.m --(CON(R.sub.1)).sub.r --(CH.sub.2).sub.s --Y.sup.1 --(CH.sub.2).sub.s --(N(R.sub.1)CO).sub.r --(CH.sub.2).sub.n --X.sup.1 --B.sup.1 --A.sup.1 The compounds of this invention are also illustrated by the Formula (II): EQU A.sup.2 --B.sup.2 --X.sup.2 --(CH.sub.2).sub.m --(N(R.sub.1)CO).sub.r --(CH.sub.2).sub.s --Y.sup.2 --(CH.sub.2).sub.s --(CON(R.sub.1)).sub.r --(CH.sub.2).sub.n --X.sup.2 --B.sup.2 --A.sup.2 The compounds have hemoregulatory activities and can be used to stimulate haematopoiesis and for the prevention and treatment of viral, fungal and bacterial infectious diseases.