Thiadiazole amide MMP inhibitors
US5830869A · kind A · utility
2Cited by
1References
28Claims
0Family size
Inventors
Key dates
| Filing date | Jun 18, 1997 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Jun 18, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis, periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, inflammation and other diseases related to connective tissue degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.