Antiproliferative vitamin D.sub.3 hybrids
US5830885A · kind A · utility
7Cited by
15References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 6, 1996 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Feb 6, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/532
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Vitamin D.sub.3 analogues of formula ##STR1## wherein R represents a 1-hydroxyalkyl group or 1-fluoroalkyl group in a trans- configuration with a 3-hydroxyl group on the A ring and R.sup.2 represents the substituents completing a vitamin D.sub.3 analogue. These novel compounds are potent anti-proliferative substances with activities comparable to that of calcitriol but with vitamin D.sub.3 receptor binding ratings of less than 10.sup.-3 compared to that of calcitriol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.