Derivatives of 6,8-difluoro-7-hydroxycoumarin
US5830912A · kind A · utility
120Cited by
13References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 15, 1996 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Nov 15, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09B57/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention comprises 6,8-difluoro-7-hydroxycoumarins and derivatives of 6,8-difluoro-7-hydroxycoumarins, including reactive dyes, dye-conjugates and enzyme substrates. These fluorine-substituted fluorescent dyes typically possess greater photostability and lower pH sensitivity in the physiological pH range than their nonfluorinated analogs, exhibit less fluorescence quenching when conjugated to a substance, possess absorption and emission spectra that closely match those of their nonfluorinated analogs, and also exhibit higher quantum yields than their nonfluorinated analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.