Nonpeptide insulin receptor agonists
US5830918A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 15, 1997 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Jan 15, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/9121
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## wherein each Ar is independently an aromatic moiety; each A is independently a proton-accepting substituent; PA1 each R is independently a noninterfering substituent; PA1 m is 0 or 1; PA1 n is 4-6; and PA1 each linker is independently an isostere of --CH.sub.2 --, --CH.dbd.CH-- or --NCHO--. Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.