Peptides which bind to prothrombin and thrombin
US5831003A · kind A · utility
3Cited by
1References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 28, 1996 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Jun 28, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21005
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Peptide ligands which bind to thrombin and prothrombin are disclosed. The sequences of these peptides are Gln-Leu-Trp-Gly-Ser-His, Arg-Gln-Leu-Trp-Gly-Ser-His, His-Gln-Leu-Trp-Gly-Ser-His, and Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. The preferred peptides have the sequence Gln-Leu-Trp-Gly-Ser-His or Tyr-Phe-Pro-Gly-Pro-Tyr-Leu. A method of using these peptides in an affinity chromatography process to purify thrombin is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.