Agent for stimulating animal cell division
US5831067A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 1995 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Aug 7, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Agents for stimulating the dividing activity of mammalian cells are presented, which have as an active substance a nucleotide sequence with a complimentary sequence (anti-sense) to a domain of the mRNA of tumor suppressor retinoblastoma or p16 genes acting on cell dividing activity. For Rb, the agents are nucleotide sequences 5'-GGTTTTGGGCGGCATGAC-3' (SEQ ID NO: 1) and 5'-CTCAGTAAAAGTGAACGA-3' (SEQ ID NO: 2); a nucleotide sequence comprising 49 base pairs, wherein the domain of the mRNA comprises nucleotides 124 to 152; and a 360 base pair nucleotide wherein the domain of the mRNA comprises an Hpa I restriction endonuclease site, an ASP718 endonuclease site, a portion of the 5' untranslated domain of the Rb gene, and a first exon of the Rb gene. For p16, the agent comprises GATCCATGCT GCTCC (SEQ ID NO: 3).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.