Method of preparing retroviral protease inhibitor intermediates
US5831117A · kind A · utility
11Cited by
1References
4Claims
0Family size
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Key dates
| Filing date | Jan 20, 1995 |
| Grant date | Nov 3, 1998 |
| Priority date | — |
| Expiry date | Jan 20, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.