Synthesis of aromatic amines from chloroamatics

US5831128A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Matthias Beller · Ostseebad Nienhagen, DE
• Thomas Riermeier · Wemding, DE
• Claus-Peter Reisinger · Wixom, US
• Wolfgang Anton Herrmann · Freising, DE
• Holger Geissler · Mainz, DE

Key dates

• Filing date: Dec 3, 1997
• Grant date: Nov 3, 1998
• Expiry date: Dec 3, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C209/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of aromatic amines of the formula (I) EQU Ar--NR.sup.1 R.sup.2 (I) in which Ar is ##STR1## and R.sup.3 to R.sup.9 independently of one another are hydrogen, C.sub.1 -C.sub.8 -alkyl, alkoxy-(C.sub.1 -C.sub.8), acyloxy-(C.sub.1 -C.sub.8), OAr, Ar, fluorine, chlorine, bromine, iodine, OH, NO.sub.2, CN, CO.sub.2 H, CHO, SO.sub.3 H, SO.sub.2 R, SOR, NH.sub.2, NH-alkyl-(C.sub.1 -C.sub.12), N-alkyl.sub.2 -(C.sub.1 -C.sub.12), NHCO-alkyl-(C.sub.1 -C.sub.12), CO-alkyl-(C.sub.1 -C.sub.12), NHCHO, COAr, CO.sub.2 Ar, CF.sub.3, CONH.sub.2, CHCHCO.sub.2 R, POAr.sub.2, PO-alkyl.sub.2 -(C.sub.1 -C.sub.12), 5-ring heteroaryl, 6-ring heteroaryl, Si-alkyl.sub.3 -(C.sub.1 -C.sub.12), where R=alkyl(C.sub.1 -C.sub.8), aryl(C.sub.5 -C.sub.10) and R.sup.1 and R.sup.2 independently of one another are hydrogen, C.sub.1 -C.sub.12 -alkyl, Ar as defined above, 5-ring heteroaryl, 6-ring heteroaryl, by reacting chloroaromatics of the formula II EQU Ar--Cl (II) with ammonia or primary or secondary amines of the formula III EQU R.sup.1 R.sup.2 NH (III) in which Ar and R.sup.1 and R.sup.2 are as defined above, which comprises reacting the starting mater…