Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US5833975A · kind A · utility
129Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1994 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | Jan 19, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Attenuated vaccinia or canarypox recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFN.gamma.; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.