Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core

US5834001A · kind A · utility

Assignee

• Brown University Research Foundation · US

Inventors

• Keith E. Dionne · Rehoboth, US
• Dwaine F. Emerich · Glocester, US
• Diane Hoffman · Cambridge, US
• Paul R. Sanberg · Spring Hill, US
• Lisa Christenson · New Haven, US
• Orion D. Hegre · Chepachet, US
• David W. Sharp · Chesterfield, US
• Paul E. Lacy · Webster Groves, US
• Patrick Aebischer · Lutry, CH
• Alfred V. Vasconcellos · Edison, US
• Michael J. Lysaght · Tigard, US
• Frank T. Gentile · East Greenwich, US

Key dates

• Filing date: May 24, 1995
• Grant date: Nov 10, 1998
• Expiry date: May 24, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells capable of secreting a biocompatible matrix comprising a hydrogel or extracellular matrix, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product or said function.