Triacetin as a penetration enhancer for transdermal delivery of a basic drug
US5834010A · kind A · utility
62Cited by
12References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 3, 1997 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | Jan 3, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P27/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pK.sub.a of about 8.0 or greater, an effective amount of a penetration enhancer consisting essentially of triacetin, and a polymer layer preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.