Lipid complexed topoisomerase I inhibitors
US5834012A · kind A · utility
21Cited by
5References
29Claims
0Family size
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Key dates
| Filing date | May 3, 1995 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | May 3, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/544
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of the base compound and displays similar cytotoxicity against both MDR-1 negative and positive tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.