Methods and compositions for identifying morphogen analogs
US5834188A · kind A · utility
10Cited by
1References
10Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 26, 1995 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | Jul 26, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are methods and compositions for identifying morphogen analogs. Preferred methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. In certain embodiments, the methods involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.