Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex
US5834228A · kind A · utility
13Cited by
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8Claims
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Key dates
| Filing date | Feb 13, 1997 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | Feb 13, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/96466
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The apopain:Ac-DEVD-CHO complex has been crystallized and its structure determined by x-ray crystallography. Based upon this crystal structure of the complex, a method for identifying inhibitors of apopain is presented which comprises designing putative inhibitors having specific contacts with apopain, making the putative inhibitors, and testing the putative inhibitors for their ability to inhibit apopain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.