Regulated apoptosis

US5834266A · kind A · utility

Assignees

• President and Fellows of Harvard College · US
• Board of Trustees Leland Stanford Jr University · US

Inventors

• Gerald R. Crabtree · Woodside, US
• Stuart L. Schreiber · Cambridge, US
• David Spencer · Houston, US
• Thomas J. Wandless · Cambridge, US
• Peter Belshaw · Madison, US

Key dates

• Filing date: Aug 18, 1994
• Grant date: Nov 10, 1998
• Expiry date: Aug 18, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.