Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same

US5834279A · kind A · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Harvey Rubin · Philadelphia, US
• Fude Yang · Wilmington, US
• David Avarbock · Lansdale, US
• Sean Curran · Leominster, US

Key dates

• Filing date: Mar 3, 1997
• Grant date: Nov 10, 1998
• Expiry date: Mar 3, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01K2217/05
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Nucleic acid molecules that encode R2 subunit protein and topoisomerase I protein, fragments thereof, recombinant expression vectors and host cells are disclosed. Oligonucleotide molecules with nucleotide sequences complimentary to a nucleotide sequence encode R2 subunit protein and topoisomerase I protein are disclosed.