Antifungal composition with enhanced bioavailability
US5834472A · kind A · utility
32Cited by
10References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 21, 1997 |
| Grant date | Nov 10, 1998 |
| Priority date | — |
| Expiry date | May 21, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/496
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical composition comprising: PA1 i) an antifungal agent which is (-)-(2R-cis)-4-4-4-4--5-(2,4-difluorophenyl)-tetrahydro-5-(1H-1,2,4-t riazol-1-ylmethyl)furan-3-yl!methoxy!phenyl!-1-piperazinyl!phenyl!-2,4-dihy dro-2-(S)-1-ethyl-2(S)-hydroxypropyl!-3H-1,2,4-triazol-3-one; PA1 ii) at least one non-ionic surfactant; and PA1 iii) a diluent. The composition enables the antifungal compound, which has very low water solubility, to have enhanced bioavailability in mammals, such as humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.