Ingap protein involved in pancreatic islet neogenesis

US5834590A · kind A · utility

Assignee

• Eastern Virginia Medical School of the Medical College of Hampton · US

Inventors

• Aaron I. Vinik · Norfolk, US
• Gary L. Pittenger · Virginia Beach, US
• Ronit Rafaeloff · Chesapeake, US
• Lawrence Rosenberg · Montréal, CA
• William P. Duguid · Montréal, CA

Key dates

• Filing date: Feb 22, 1995
• Grant date: Nov 10, 1998
• Expiry date: Feb 22, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.