Cationic lipid compositions targeting angiogenic endothelial cells
US5837283A · kind A · utility
34Cited by
8References
13Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 12, 1997 |
| Grant date | Nov 17, 1998 |
| Priority date | — |
| Expiry date | Mar 12, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.