Hox-induced enhancement of in vivo and in vitro proliferative capacity and gene therapeutic methods

US5837507A · kind A · utility

Assignees

• The Regents of the University of California · US
• Keith Humphries · US
• Guy Sauvageau · US

Inventors

• Corey Largman · Chino Hills, US
• Hugh Jeffrey LAWRENCE · Lafayette, US
• R. Keith Humphries · Burns Lake, CA
• Guy Sauvageau · Montréal, CA

Key dates

• Filing date: Nov 13, 1995
• Grant date: Nov 17, 1998
• Expiry date: Nov 13, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K48/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Stem cells transduced with HOXB4 exhibit enhanced in vitro and in vivo ability for self-regeneration and generate higher-numbers of tranplantable pluripotent hematopoietic stem cells relative to control and nonmanipulated cells.