Inhibition of the mitogenic activity of PDGF by mammalian EGr
US5837692A · kind A · utility
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9Claims
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Inventors
Key dates
| Filing date | Apr 7, 1994 |
| Grant date | Nov 17, 1998 |
| Priority date | — |
| Expiry date | Apr 7, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to methods for inhibiting the growth in vitro or in an individual of a tumor cell induced by the mitogenic activity of PDGF by transfecting the cell with an expression vector having an expression control sequence operatively linked to a nucleic acid sequence encoding a mammalian EGR, a nucleic acid sequence encoding a fragment of a mammalian EGR comprising the three zinc fingers or a nucleic acid sequence that hybridizes to any of the foregoing nucleic acid sequences under standard hybridization conditions and that encodes a polypeptide having the cell growth-inhibiting activity of Egr-1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.