Method of inhibiting cancer growth

US5837696A · kind A · utility

Assignees

• The Research Foundation of the State University of New York · US
• The University of Miami · US

Inventors

• Lorne M. Golub · Smithtown, US
• Thomas F. McNamara · Port Jefferson, US
• Nungavaram S. Ramamurthy · Smithtown, US
• Hsi-Ming Lee · Setauket, US
• Sanford Simon · Stony Brook, US
• Balakrishna L. Lokeshwar · Miami, US
• Marie Selzer · Fort Lauderdale, US
• Norman L. Block · Miami, US

Key dates

• Filing date: Jan 15, 1997
• Grant date: Nov 17, 1998
• Expiry date: Jan 15, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.