Process to prepare oxazolidinones

US5837870A · kind A · utility

Assignee

• Pharmacia & Upjohn Company LLC · US

Inventors

• Bruce Allen Pearlman · Kalamazoo, US
• William R. Perrault · Kalamazoo, US
• Michael R. Barbachyn · Kalamazoo, US
• Peter R. Manninen · Portage, US
• Dana S. Toops · Kalamazoo, US
• David J. Houser · Portage, US
• Thomas J. Fleck · Scotts, US

Key dates

• Filing date: Mar 28, 1997
• Grant date: Nov 17, 1998
• Expiry date: Mar 28, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).