Drug delivery composition containing chitosan or derivative thereof having a defined z. potential
US5840341A · kind A · utility
43Cited by
1References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 21, 1997 |
| Grant date | Nov 24, 1998 |
| Priority date | — |
| Expiry date | Apr 21, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2982
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A drug delivery composition for administration to mucosa is provided. The composition includes a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are either solidified or partially cross-linked such that they have a zeta potential of +0.5 to +50 mV. Solidified particles are made by treating particles made from a water soluble chitosan salt with an alkaline agent such as sodium hydroxide in a non-acid containing water to render them insoluble.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.